In an interview with the Toronto-based In Magazine (via The Playlist), the great John Lithgow admits that he was offered the part of Seth Brundle in David Cronenbergs 1986 version of The Fly, but passed on the role because it was "icky." Said Lithgow:
Jeff Goldblum, on the flipside, was coming off of 1983s The Big Chill, and had 1985s Transylvania 6-5000 in the can before he took on The Fly. And while David Cronenbergs movie has been one of the movies that turned him into a viable leading man, it probably still ranks right behind Jurassic Park on a list of "definitive" roles for Jeff Goldblum. I mean, how does Brundle Fly possibly hope to contend against the ridiculously confident Dr. Ian Malcolm?
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