Del Toro shared that the design of the Strigoi and the design for the Reapers from Blade II shared a common origin. Here's where he says it all began.
As much as Blade II has influenced Guillermo Del Toro's work on the series, the 1997 sleeper hit, Mimic is also important to the genesis of The Strain. While Mimic barely resembles the original Del Toro pitch, The Strain's improvements on both Mimic's story, as well as Blade II's monster design seem to denote that Guillermo Del Toro sort-of used The Strain as a second draft of concepts he's really in love with. If you mix together Mimic's epidemic-heavy storyline with Blade II's vampiric Illuminati trying to undermine all human authority, you have a blueprint for the war that's being waged on the streets of New York in the world of Ephraim Goodweather and his companions.
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