She passed away peacefully in a Manchester hospital following a short illness, her husband confirmed tonight.
Kirkbride first appeared in the long-running ITV soap in 1972, and played her much-loved character for 43 years.
In September, she announced she was taking a three month break from the show, and was expected to return to Coronation Street this month, the Mirror reported.
A statement on the ITV website said her husband David Beckett and the programme's cast and crew are "heartbroken and deeply saddened".
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