Amelie, set in Montmartre, was a critical and box office success in which Tautou played a shy waitress who set out to improve the lives of those around her.
Tautou's latest film L'Ecume des Jours ('Mood Indigo') by director Michel Gondry, opens in France later this month.
An adaptation of the Francois Mauriac novel Therese Desqueyroux, in which she starred, closed the festival last year.
The 2012 opening and closing ceremonies were hosted by The Artist star Berenice Bejo.
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