Lee County is a county located in the U.S. state of Mississippi. As of 2010, the population was 82,910. The county seat is Tupelo. It is the largest county in the Tupelo Micropolitan Statistical Area. Lee County is named for General Robert E. Lee.
According to the U.S. Census Bureau, the county has a total area of 453 square miles (1,173.3 km), of which 450 square miles (1,165.5 km) is land and 4 square miles (10.4 km) (0.78%) is water.
On September 20, 1816, General Andrew Jackson, David Meriwether, and the Chickasaw Nation signed the Treaty of Chickasaw Council House in Lee County.
Lee County was formed on October 26, 1866 from parts of Itawamba and Pontotoc Counties. It was named for General Robert E. Lee, General-in-Chief of the Armies of the Confederate States.
As of the census of 2000, there were 75,755 people, 29,200 households, and 20,819 families residing in the county. The population density was 168 people per square mile (65/km²). There were 31,887 housing units at an average density of 71 per square mile (27/km²). The racial makeup of the county was 73.66% White, 24.51% Black or African American, 0.13% Native American, 0.52% Asian, 0.01% Pacific Islander, 0.43% from
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