Saline County is a county located in the U.S. state of Nebraska. As of 2010, the population was 14,200. Its county seat is Wilber.
In the Nebraska license plate system, Saline County is represented by the prefix 22 (it had the twenty-second-largest number of vehicles registered in the county when the license plate system was established in 1922).
According to the U.S. Census Bureau, the county has a total area of 576 square miles (1,492 km²), of which, 575 square miles (1,490 km²) of it is land and 1 square miles (2 km²) of it (0.13%) is water.
As of the census of 2000, there were 13,843 people, 5,188 households, and 3,507 families residing in the county. The population density was 24 people per square mile (9/km²). There were 5,611 housing units at an average density of 10 per square mile (4/km²). The racial makeup of the county was 92.99% White, 0.36% Black or African American, 0.38% Native American, 1.70% Asian, 0.03% Pacific Islander, 3.40% from other races, and 1.15% from two or more races. 6.58% of the population were Hispanic or Latino of any race.
There were 5,188 households out of which 32.80% had children under the age of 18 living with them, 56.50% were married couples
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